GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs703842 | 1 | rs10877015 | chr12:58167788 | TSFM | chr12:58176536-58191367:+ | -0.33 | -9.85 | 5.67E-22 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10877015 | chr12:58167788 | XRCC6BP1 | chr12:58335445-58351051:+ | -0.17 | -4.78 | 2.01E-6 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10877019 | chr12:58172929 | B4GALNT1 | chr12:58019551-58026985:- | -0.13 | -3.65 | 0.000274 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10877019 | chr12:58172929 | FAM119B | chr12:58166383-58176323:+ | -0.43 | -10.47 | 1.67E-24 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10877019 | chr12:58172929 | RDH16 | chr12:57345218-57396703:- | -0.14 | -3.43 | 0.00062 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10877019 | chr12:58172929 | TSFM | chr12:58176536-58191367:+ | 0.35 | 10.22 | 1.93E-23 | Multiple sclerosis |
| BRCA | cis | rs703842 | 1 | rs10877019 | chr12:58172929 | XRCC6BP1 | chr12:58335445-58351051:+ | 0.17 | 4.66 | 3.54E-6 | Multiple sclerosis |
| BRCA | cis | rs11174436 | 1 | rs10877820 | chr12:62672756 | FAM19A2 | chr12:62102043-62653925:- | 0.17 | 3.68 | 0.000247 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs11174436 | 1 | rs10877826 | chr12:62713960 | FAM19A2 | chr12:62102043-62653925:- | 0.18 | 3.8 | 0.00015 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs11174436 | 1 | rs10877834 | chr12:62788811 | FAM19A2 | chr12:62102043-62653925:- | 0.17 | 3.66 | 0.000262 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs11174436 | 1 | rs10877846 | chr12:62824366 | FAM19A2 | chr12:62102043-62653925:- | 0.17 | 3.6 | 0.000333 | Pyoderma gangrenosum in inflammatory bowel disease |
| BRCA | cis | rs10877945 | 1 | rs10877942 | chr12:63416152 | PPM1H | chr12:63037763-63328915:- | -0.13 | -3.43 | 0.000637 | Obesity-related traits |
| BRCA | cis | rs10877945 | 1 | rs10877944 | chr12:63430109 | PPM1H | chr12:63037763-63328915:- | -0.14 | -3.67 | 0.000254 | Obesity-related traits |
| BRCA | cis | rs17101923 | 1 | rs10878346 | chr12:66320873 | LLPH | chr12:66516850-66563807:- | 0.16 | 3.93 | 9.22E-5 | Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth) |
| BRCA | cis | rs11185790 | 1 | rs10881608 | chr10:91374649 | FLJ37201 | chr10:91451057-91457685:- | -0.17 | -3.76 | 0.000178 | Metabolic traits |